Undetected diabetes linked to heart attack and gum disease

People with undetected glucose disorders run a higher risk of both myocardial infarction and periodontitis, according to a study published in the journal Diabetes Care by researchers at Karolinska Institutet in Sweden. The results demonstrate the need of greater collaboration between dentistry and healthcare, say the researchers, and possibly of screening for diabetes at dental clinics.

Severe periodontitis is already known to be associated with a higher risk of myocardial infarction and lowered glucose tolerance, and diabetes to be more common in people who have suffered a heart attack.

The researchers behind these earlier findings have now studied whether undetected glucose disorders (dysglycaemia) -- that is, a reduced ability to metabolise sugar -- is linked to both these conditions: myocardial infarction and periodontitis. The results are published in the journal Diabetes Care. The study was a collaboration between cardiologists and dentists at Karolinska Institutet and was based on data from a previous study called PAROKRANK. It included 805 myocardial infarction patients from 17 Swedish cardiology clinics and 805 controls, who were matched by age, sex and post code. The patients' periodontitic status was assessed with X-rays and dysglycaemic status with glucose load tests.

Recreational cyborgs. There are already famous examples of real-life cyborgs, and I am truly convinced that such creatures will not only populate the terrain of sci-fi movies, but they will be everywhere around us in the very near future. The ‘cyborg-craze’ will eventually start with a new generation of hipsters who implant devices and technologies in their bodies just to look cooler. Advances in future medical technology will not just repair physical disadvantages such as impaired eyesight but will create superhuman powers from having the eyesight of an eagle to having the hearing of a bat. While a patient wearing implanted defibrillators or pacemakers can also be added to the group of cyborgs, I expect to see more cases when patients ask for the implantation of a certain device without having medical problems.

Participants with a diabetes diagnosis were excluded from the study, which left 712 patients and 731 controls with data on both periodontitic status and glucose status, the latter of which was divided into three categories: normal, reduced glucose tolerance, newly detected diabetes. Comparisons were made after adjusting for age, sex, smoking habits, education and civil status.

The study shows that previously undetected glucose disorders, which include diabetes and impaired glucose tolerance, were linked to myocardial infarction. It was roughly twice as common for myocardial infarction patients to have undetected dysglycaemia as for healthy controls, confirming the research group's earlier findings. Myocardial infarction affects approximately 30,000 people in Sweden annually.

Undetected diabetes was also found to be linked to severe periodontitis. When myocardial infarction patients and controls were analysed separately, the association was clearer in the patients than in the controls, which is possibly because many of the controls were very healthy and few had severe periodontitis and undetected diabetes.

"Our findings indicate that dysglycaemia is a key risk factor in both severe periodontitis and myocardial infarction and that the combination of severe periodontitis and undetected diabetes further increases the risk of myocardial infarction," says the study's lead author Anna Norhammar, cardiologist and Associate Professor at Karolinska Institutet's Department of Medicine in Solna.

Medical technology innovations: A Valve Job with Heart. The Sapien transcatheter aortic valve is a life-saving alternative to open-heart surgery for patients who need new a new valve but can't endure the rigors of the operation. Manufactured by Edwards Life Sciences (Irvine, CA), the Sapien has been available in Europe for some time but is only now finding its first use in U.S. heart centers—where it is limited only to the frailest patients thus far. The Sapien valve is guided through the femoral artery by catheter from a small incision near the grown or rib cage. The valve material is made of bovine tissue attached to a stainless-steel stent, which is expanded by inflating a small balloon when correctly placed in the valve space. A simpler procedure that promises dramatically shorter hospitalizations is bound to have a positive effect on the cost of care.

The results substantiate previously known links between periodontitis and diabetes and show that such an association also exists in previously unknown diabetes.

According to the researchers, the findings should make diabetes specialists consider their patients' dental health and the need for closer collaboration with dentists.

"The PAROKRANK study is a good example of such collaboration," says the present study's senior author Lars Rydén, Professor at Karolinska Institutet's Department of Medicine in Solna and chair of the academically initiated PAROKRANK study.
"Our study shows that undetected glucose disorders are common in two major diseases -- myocardial infarction and periodontitis," says Dr Norhammar. "Many people visit the dentist regularly and maybe it's worth considering taking routine blood-sugar tests in patients with severe periodontitis to catch these patients."

One of the study's limitations is that despite the large number of participants, the number of patients and controls with severe periodontitis and undetected diabetes was low. The observed differences in the links between undetected diabetes and severe periodontitis in patients and controls can therefore be attributable either to the low number of patients or to genuine differences in correlation.

Downloading Your Consciousness. This technology comes straight out of a comic book. The notion behind this technology is that one day people will be able to live in computers for thousands of years. The idea is that a computer will have all your information on it integrated with artificial intelligence that would allow us humans to live within a computer. This is presented by a scientist Ian Pearson who is working on this technology as you are reading this article. It is said that by 2050, if you make for that long, this technology will be ready and we will have our very own silicon soul.

The study was financed with grants from AFA Insurance, the Swedish Heart and Lung Foundation, the Swedish Research Council and Region Stockholm (ALF funding).

Medtronic’s HeartWare device reduces strokes in trial subjects
Medtronic’s HeartWare device reduces strokes in trial subjects
DNA and RNA Copying made easy
DNA and RNA Copying made easy
Study affirms self-reported sleep duration as a useful health measure in children
Study affirms self-reported sleep duration as a useful health measure in children
Worsening of overdose crisis predicted: Limits of focusing on prescription opioids
Worsening of overdose crisis predicted: Limits of focusing on prescription opioids
Early-life exposure to microbiota restricts colon cancer later in life, study finds
Early-life exposure to microbiota restricts colon cancer later in life, study finds
Mediterranean-style diet may lower women's stroke risk
Mediterranean-style diet may lower women's stroke risk