Now, researchers comparing American, Pacific and Southeast Asian subtypes of the virus in PLOS Neglected Tropical Diseases have concluded that the American-subtype strain has the highest ability to grow both in vitro and in vivo.
Mazzotti, PhD, and co-authors report on a study of adults with moderate to severe OSA who were categorized into four subtypes according to the symptoms they report: disturbed sleep, minimally symptomatic, moderately sleepy and excessively sleepy.
"Part of precision medicine is an accurate molecular diagnosis, which this study provides to more patients." A novel subtype-defining alteration Alterations of the transcription factor gene PAX5 defined two new subtypes, including PAX5 P80R, as the first lymphoblastic leukemia initiated by a point mutation.
In the journal Nature, UNC Lineberger's Thomas Alexander, MD, MPH, along with co-first authors Zhaohui Gu, PhD, and Ilaria Iacobucci, PhD, of St. Jude, and corresponding authors Charles Mullighan, MBBS, MD, and Hiroto Inaba, MD, PhD, also of St. Jude, and colleagues reported findings about the genetics of mixed phenotype acute leukemia (MPAL), a type of cancer with features of both acute myeloid leukemia (AML) and acute lymphoblastic leukemia (ALL).
"These findings suggest that the founding mutation occurs early in blood cell development, in some cases in hematopoietic stem cells, and results in an acute leukemia with features of both myeloid and lymphoid cells," said Thomas Alexander, M.D., formerly of St. Jude and now of the University of North Carolina at Chapel Hill.