Are American Zika strains more virulent than Pacific and Asian strains?

Are American Zika strains more virulent than Pacific and Asian strains?

Now, researchers comparing American, Pacific and Southeast Asian subtypes of the virus in PLOS Neglected Tropical Diseases have concluded that the American-subtype strain has the highest ability to grow both in vitro and in vivo.

Reservoir bugs: Study shows why stomach pathogen is so tough to eradicate

Reservoir bugs: Study shows why stomach pathogen is so tough to eradicate

pylori establish their chronic persistence in the body," said Manuel Amieva, MD, PhD, associate professor of pediatrics and of microbiology and immunology, who is the study's senior author.

Researchers investigate resorbable mesh potential for sports injuries

Researchers investigate resorbable mesh potential for sports injuries

The synthetic and fully resorbable TIGR Matrix surgical mesh by Novus Scientific is currently being investigated by researchers in the Erasmus University Medical Center in Rotterdam, the Netherlands.

Low-calorie sweetener derived from lactose gets manufacturing boost from yeast

Low-calorie sweetener derived from lactose gets manufacturing boost from yeast

Yong-Su Jin, a University of Illinois professor of food science and human nutrition, led the research team that engineered the yeast strain, which produces tagatose in much larger quantities than traditional enzymatic manufacturing techniques and could help make tagatose a cost-effective alternative to sugar or high-fructose corn syrup.

Petting zoos could potentially transmit highly virulent drug-resistant bacteria to visitors

Petting zoos could potentially transmit highly virulent drug-resistant bacteria to visitors

The study found that petting zoos provide a reservoir for a diverse range of ESBL/AmpC-E species, and are a potential source for shedding these highly virulent pathogens that may be transmitted to humans -- mostly children -- that occasionally visit these facilities.

Genetic code of WWI soldier's cholera mapped

Genetic code of WWI soldier's cholera mapped

The oldest publicly-available strain of the cholera-causing bacterial species, Vibrio cholerae, has had its genetic code read for the first time by researchers at the Wellcome Sanger Institute and their collaborators.

Researchers engineer a cost-effective treatment for neglected tropical disease

Researchers engineer a cost-effective treatment for neglected tropical disease

"The gene cluster in the fungus is unique -- through a simple genetic deletion, we have engineered a strain of the fungus that only produces high concentrations of the desired antibiotic," explained Abe. Professor Kiyoshi Kita, who retired from the University of Tokyo in 2016, dedicated a large portion of his career to understanding and curing African sleeping sickness.

High throughput method to produce and screen engineered antimicrobial lanthipeptides

High throughput method to produce and screen engineered antimicrobial lanthipeptides

Molecular biologists from the University of Groningen and their colleagues in Switzerland and Germany have now developed a pipeline to create and screen large numbers of new lantibiotic peptides. When the beads were incubated, the producer strain formed a single colony inside, secreting lantibiotics.

Antibodies from earlier exposures affect response to new flu strains

Antibodies from earlier exposures affect response to new flu strains

"After being vaccinated with a new strain of flu, our immune systems appear to be expanding and boosting antibodies generated by previous exposures to earlier flu viruses, whether by infection or vaccination," said George Georgiou, a professor of biomedical and chemical engineering and molecular biosciences, a leader in the field of therapeutics and immune responses and co-author of the study.

How genetic background shapes individual differences within a species

How genetic background shapes individual differences within a species

In an earlier work, the Boone and Andrews labs, in collaboration with Fink's group, established that mutations in 57 genes, about one percent of all yeast genes, have different outcomes between SC and Sigma, causing cell death in either one or the other strain, but not both.

Why a blow to the chest can kill or save you

Why a blow to the chest can kill or save you

Researchers at EPFL's Soft Transducers Laboratory and at the Department of Physiology of the University of Bern (Group Rohr) have developed an experimental device that lets scientists subject bioengineered heart tissue to highly dynamic strain cycles and measure its electrophysiological response.

More efficient system to reprogram stem cells

More efficient system to reprogram stem cells

The new Mayo process combines those factors within the measles virus vector so the process happens in one step and all targeted cells have the potential to reprogram.

The web meets genomics: A DNA search engine for microbes

The web meets genomics: A DNA search engine for microbes

The search engine, described in a paper published in Nature Biotechnology, could enable researchers and public health agencies to use genome sequencing data to monitor the spread of antibiotic resistance genes.

Small metabolites have big effects on the intestinal immune response

Small metabolites have big effects on the intestinal immune response

Mice lacking GPR31 showed reduced dendrite protrusion by CX3CR1+ cells after being administered pyruvate or lactate and, as a result, decreased antibody production following infection with a non-pathogenic strain of Salmonella.

Printer for microparts suited to tissue engineering launched

Printer for microparts suited to tissue engineering launched

Once the user has designed a 3D model using standard CAD tools and chosen an appropriate polymer material, Microlight3D's algorithms calculate the path that the laser will take to create the object.

Mystery of Yemen cholera epidemic solved

Mystery of Yemen cholera epidemic solved

Through the use of genomic sequencing, scientists at the Wellcome Sanger Institute and Institut Pasteur estimate the strain of cholera causing the current outbreak in Yemen -- the worst cholera outbreak in recorded history -- came from Eastern Africa and entered Yemen with the migration of people in and out of the region.

Bacteria found in ancient Irish soil halts growth of superbugs: New hope for tackling antibiotic resistance

Bacteria found in ancient Irish soil halts growth of superbugs: New hope for tackling antibiotic resistance

Researchers analysing soil from Ireland long thought to have medicinal properties have discovered that it contains a previously unknown strain of bacteria which is effective against four of the top six superbugs that are resistant to antibiotics, including MRSA.

Whether a urinary tract infection recurs may depend on the bacterial strain

Whether a urinary tract infection recurs may depend on the bacterial strain

Genetically diverse bacterial strains that cause urinary tract infections differ in their ability to trigger protective immune responses in mice, potentially explaining why these infections frequently recur in many patients, according to a study published December 13 in the open-access journal PLOS Pathogens by Thomas Hannan and Scott Hultgren of Washington University School of Medicine, and colleagues.

Sugars and microbiome in mother's milk influence neonatal rotavirus infection

Sugars and microbiome in mother's milk influence neonatal rotavirus infection

Using a multidisciplinary approach, an international team of researchers from several institutions, including Baylor College of Medicine, reveals that complex interactions between sugars and the microbiome in human milk influence neonatal rotavirus infection.

Small RNA renders bacteria more resistant to antibiotics: Some soil bacteria have considerable penicillin tolerance

Small RNA renders bacteria more resistant to antibiotics: Some soil bacteria have considerable penicillin tolerance

In the journal mBio, published online on 13 November 2018, the team headed by Jessica Borgmann from the Chair of Microbial Biology describes a small RNA molecule that significantly affects antibiotic resistance as well as other processes inside the cell.

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