Now, researchers comparing American, Pacific and Southeast Asian subtypes of the virus in PLOS Neglected Tropical Diseases have concluded that the American-subtype strain has the highest ability to grow both in vitro and in vivo.
Published in Human Vaccines & Immunotherapeutics, the study uses modern day scientific technology and delves through literature published in The Lancet from the time, to not only track the origins of the virus, but to seek how we can use this information to learn from the past to prevent the spread of an influenza pandemic.
A growing number of infections -- such as pneumonia, gonorrhea and tuberculosis -- are becoming harder to treat, as bacteria evolve defenses against antibiotics faster than we can develop new drugs to replace them.
A new study from The Westmead Institute for Medical Research has uncovered how serious fungal infections grow in humans by conserving phosphate, highlighting a possible target for treatment. Lead researcher, Associate Professor Julie Djordjevic, said, "This is the first time that this strategy of conserving phosphate has been described in a human fungal pathogen.
We are uniquely placed between the NHS and industry, and this Digital Health Accelerator will make the most of that relationship to help companies navigate the healthcare system and maximise on their innovations.
Researchers from The University of Queensland and Swansea University have been looking at how different environments provide opportunities for animal-to-human diseases -- known as zoonotic diseases -- to interact with and infect new host species, including humans.
Rather than killing host cells infected by Listeria in the gastrointestinal tract, the RIPK3 and MLKL proteins recognize the chemical composition of the bacteria and MLKL binds to it, preventing the spread of Listeria while keeping the host cells alive.
Global warming has allowed mosquitoes, ticks and other disease-carrying insects to proliferate, adapt to different seasons, and invade new territories across Europe over the past decade -- with accompanying outbreaks of dengue in France and Croatia, malaria in Greece, West Nile Fever in Southeast Europe, and chikungunya virus in Italy and France.
Scientists at the University of California San Diego have now developed a new version of a gene drive that opens the door to the spread of specific, favorable subtle genetic variants, also known as "alleles," throughout a population.
"While the association between this gene and HCC is well recognized, in this review we see AKR1B10 emerging as not only a therapeutic target for this type of liver cancer, but also having potential use in early diagnosis of this deadly disease," said Dr. Johanna DiStefano, head of the Diabetes and Fibrotic Disease Unit at TGen. Importantly, AKR1B10 has a seemingly conflicting role in HCC development and progression.
A new study out today in Cancer Cell shows that blocking specific regions of a protein called UHRF1 switches on hundreds of cancer-fighting genes, impairing colorectal cancer cells' ability to grow and spread throughout the body.
In today's Nature Microbiology, a large group of international collaborators combined these factors into prediction models that offer insight into the recent spread of two key disease-spreading mosquitoes -- Aedes aegypti and Aedes albopictus.
Developing treatments that target the chemicals that alter the immune system could help to prevent the spread of the disease." Researchers also found that one of the chemicals released by Myosin II-rich cells, called interleukin 1A, was key for making cancer cells more invasive.
Through the use of genomic sequencing, scientists at the Wellcome Sanger Institute and Institut Pasteur estimate the strain of cholera causing the current outbreak in Yemen -- the worst cholera outbreak in recorded history -- came from Eastern Africa and entered Yemen with the migration of people in and out of the region.
"Compared with traditional intervention strategies that may overlook a considerable number of invisible colonized patients, this new model-inference system can identify a pivotal group for treatment, namely individuals who may otherwise transmit MRSA asymptomatically," says first author Sen Pei, a postdoctoral research scientist in the Department of Environmental Health Sciences at the Columbia Mailman School.
That change can be attributed to the implementation, beginning in 2012, of single dose rifampicin as a preventive to spread leprosy through households, researchers report in PLOS Neglected Tropical Diseases this week.