Are American Zika strains more virulent than Pacific and Asian strains?

Are American Zika strains more virulent than Pacific and Asian strains?

Now, researchers comparing American, Pacific and Southeast Asian subtypes of the virus in PLOS Neglected Tropical Diseases have concluded that the American-subtype strain has the highest ability to grow both in vitro and in vivo.

Spanish flu may have lingered two years before 1918 outbreak and vaccine could have treated it

Spanish flu may have lingered two years before 1918 outbreak and vaccine could have treated it

Published in Human Vaccines & Immunotherapeutics, the study uses modern day scientific technology and delves through literature published in The Lancet from the time, to not only track the origins of the virus, but to seek how we can use this information to learn from the past to prevent the spread of an influenza pandemic.

Could better tests help reverse the rise of drug-resistant infections?

Could better tests help reverse the rise of drug-resistant infections?

A growing number of infections -- such as pneumonia, gonorrhea and tuberculosis -- are becoming harder to treat, as bacteria evolve defenses against antibiotics faster than we can develop new drugs to replace them.

New research uncovers how life-threatening fungal diseases adapt to survive in humans

New research uncovers how life-threatening fungal diseases adapt to survive in humans

A new study from The Westmead Institute for Medical Research has uncovered how serious fungal infections grow in humans by conserving phosphate, highlighting a possible target for treatment. Lead researcher, Associate Professor Julie Djordjevic, said, "This is the first time that this strategy of conserving phosphate has been described in a human fungal pathogen.

East Midlands Digital Health Accelerator open for applications

East Midlands Digital Health Accelerator open for applications

We are uniquely placed between the NHS and industry, and this Digital Health Accelerator will make the most of that relationship to help companies navigate the healthcare system and maximise on their innovations.

Changing climate may affect animal-to-human disease transfer

Changing climate may affect animal-to-human disease transfer

Researchers from The University of Queensland and Swansea University have been looking at how different environments provide opportunities for animal-to-human diseases -- known as zoonotic diseases -- to interact with and infect new host species, including humans.

Cell-killing proteins suppress listeria without killing cells

Cell-killing proteins suppress listeria without killing cells

Rather than killing host cells infected by Listeria in the gastrointestinal tract, the RIPK3 and MLKL proteins recognize the chemical composition of the bacteria and MLKL binds to it, preventing the spread of Listeria while keeping the host cells alive.

Experts sound alarm as mosquito- and tick-borne diseases set to flourish in warmer climate

Experts sound alarm as mosquito- and tick-borne diseases set to flourish in warmer climate

Global warming has allowed mosquitoes, ticks and other disease-carrying insects to proliferate, adapt to different seasons, and invade new territories across Europe over the past decade -- with accompanying outbreaks of dengue in France and Croatia, malaria in Greece, West Nile Fever in Southeast Europe, and chikungunya virus in Italy and France.

CRISPR-based 'allelic drive' allows genetic editing with selective precision and broad implications

CRISPR-based 'allelic drive' allows genetic editing with selective precision and broad implications

Scientists at the University of California San Diego have now developed a new version of a gene drive that opens the door to the spread of specific, favorable subtle genetic variants, also known as "alleles," throughout a population.

Genes linked with the most common liver cancer

Genes linked with the most common liver cancer

"While the association between this gene and HCC is well recognized, in this review we see AKR1B10 emerging as not only a therapeutic target for this type of liver cancer, but also having potential use in early diagnosis of this deadly disease," said Dr. Johanna DiStefano, head of the Diabetes and Fibrotic Disease Unit at TGen. Importantly, AKR1B10 has a seemingly conflicting role in HCC development and progression.

Blocking epigenetic Swiss army knife may be a new strategy for treating colorectal cancer

Blocking epigenetic Swiss army knife may be a new strategy for treating colorectal cancer

A new study out today in Cancer Cell shows that blocking specific regions of a protein called UHRF1 switches on hundreds of cancer-fighting genes, impairing colorectal cancer cells' ability to grow and spread throughout the body.

Fast-changing genetics key to hospital superbug survival

Fast-changing genetics key to hospital superbug survival

The team used whole genome DNA sequence data to reconstruct the evolution of the highly drug-resistant bacteria, including tracking their transmission within the hospital, spanning three campuses, 19 wards and two intensive care units.

Forecasting mosquitoes' global spread

Forecasting mosquitoes' global spread

In today's Nature Microbiology, a large group of international collaborators combined these factors into prediction models that offer insight into the recent spread of two key disease-spreading mosquitoes -- Aedes aegypti and Aedes albopictus.

Can a nerve injury trigger ALS?

Can a nerve injury trigger ALS?

In their study, Loeb and colleagues used rats with mutated forms of the SOD1 gene, which causes the animals to have higher levels of the SOD1 enzyme and to develop ALS-like symptoms, including progressive muscle weakness, starting at 15 weeks of age.

Skin cancer can spread in mice by hijacking the immune system

Skin cancer can spread in mice by hijacking the immune system

Developing treatments that target the chemicals that alter the immune system could help to prevent the spread of the disease." Researchers also found that one of the chemicals released by Myosin II-rich cells, called interleukin 1A, was key for making cancer cells more invasive.

Combination blood test may help detect pancreatic cancer early

Combination blood test may help detect pancreatic cancer early

A research team from Van Andel Research Institute (VARI) in the US has developed a new blood test that could be used in combination with an existing test to diagnose pancreatic cancer in the disease’s early stages.

Mystery of Yemen cholera epidemic solved

Mystery of Yemen cholera epidemic solved

Through the use of genomic sequencing, scientists at the Wellcome Sanger Institute and Institut Pasteur estimate the strain of cholera causing the current outbreak in Yemen -- the worst cholera outbreak in recorded history -- came from Eastern Africa and entered Yemen with the migration of people in and out of the region.

Computer model shows how to better control MRSA outbreaks

Computer model shows how to better control MRSA outbreaks

"Compared with traditional intervention strategies that may overlook a considerable number of invisible colonized patients, this new model-inference system can identify a pivotal group for treatment, namely individuals who may otherwise transmit MRSA asymptomatically," says first author Sen Pei, a postdoctoral research scientist in the Department of Environmental Health Sciences at the Columbia Mailman School.

Leprosy declines in Morocco after implementation of preventive drug

Leprosy declines in Morocco after implementation of preventive drug

That change can be attributed to the implementation, beginning in 2012, of single dose rifampicin as a preventive to spread leprosy through households, researchers report in PLOS Neglected Tropical Diseases this week.

Pathogen predicament: How bacteria propel themselves out of a tight spot

Pathogen predicament: How bacteria propel themselves out of a tight spot

Almost all swimming species of bacteria propel themselves forward using corkscrew-like propellers called "flagella." Bacterial flagella are composed of thousands of protein building blocks arranged in spiralling chains.

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