Are American Zika strains more virulent than Pacific and Asian strains?

Are American Zika strains more virulent than Pacific and Asian strains?

Now, researchers comparing American, Pacific and Southeast Asian subtypes of the virus in PLOS Neglected Tropical Diseases have concluded that the American-subtype strain has the highest ability to grow both in vitro and in vivo.

Preventive measures can reduce foot parasite in children

Preventive measures can reduce foot parasite in children

Public health policies such as sealing house and classroom floors and daily feet washing with soap could cut the number of tungiasis cases in school-aged children, researchers now report in PLOS Neglected Tropical Diseases.

Topical cream found as less-toxic therapy to treat cutaneous leishmaniasis

Topical cream found as less-toxic therapy to treat cutaneous leishmaniasis

Paromomysin-based topical treatments were shown to be effective in curing cutaneous leishmaniasis (CL), according to a randomized, double blind study conducted in Panama and published with PLOS Neglected Tropical Diseases.

Dengue research in the Philippines evolving over time

Dengue research in the Philippines evolving over time

Now, researchers reporting in PLOS Neglected Tropical Diseases have reviewed 60 years of published literature on dengue in the country to identify trends in previous studies and areas where more research is needed.

Researchers engineer a cost-effective treatment for neglected tropical disease

Researchers engineer a cost-effective treatment for neglected tropical disease

"The gene cluster in the fungus is unique -- through a simple genetic deletion, we have engineered a strain of the fungus that only produces high concentrations of the desired antibiotic," explained Abe. Professor Kiyoshi Kita, who retired from the University of Tokyo in 2016, dedicated a large portion of his career to understanding and curing African sleeping sickness.

Modelled climate change impact on mosquito-borne virus transmission

Modelled climate change impact on mosquito-borne virus transmission

A study published on March 28, 2019, in PLOS Neglected Tropical Diseases predicts that climate change and rising global temperatures will lead to both increased and new exposures to humans of diseases carried by mosquito vectors Aedes aegypti and Ae. The most extreme instances of transmission are predicted to occur at intermediate climate change scenarios.

Vaccine study confirms sensitivity of cholera test

Vaccine study confirms sensitivity of cholera test

Researchers reporting in PLOS Neglected Tropical Diseases investigated this claim using a 'vaccine probe' analysis of a completed cholera vaccine cluster randomized trial to support the sensitivity of conventional microbiological culture for cholera.

How does the body respond to diffuse cutaneous leishmaniasis?

How does the body respond to diffuse cutaneous leishmaniasis?

For the first time, researchers reporting in PLOS Neglected Tropical Diseases have now profiled how the human immune system responds to a DCL infection and, in turn, how Leishmania amazonensis adapts to the human host.

Seasonal and geographic trends in syphilis

Seasonal and geographic trends in syphilis

Researchers reporting in PLOS Neglected Tropical Diseases have now analyzed temporal and demographic patterns in gestational syphilis (GS) and mother-to-child-transmission (MTCT) of syphilis. In many cities, however, the number of MTCT cases was larger than the number of reported GS cases, suggesting a failure in the notification system.

Contact with monkeys and apes puts populations at risk

Contact with monkeys and apes puts populations at risk

Now, researchers reporting in PLOS Neglected Tropical Diseases have carried out an extensive social sciences evaluation of how populations in Cameroon interact with nonhuman primates, pointing toward behaviors that could put people at risk of infection with new diseases.

Speed up public health decisions on scabies by skipping full-body exams

Speed up public health decisions on scabies by skipping full-body exams

Now, researchers reporting in PLOS Neglected Tropical Diseases have found that an exam of just a patient's hands, feet and lower legs may have the potential to catch more than 90 percent of all scabies cases, regardless of severity.

Leprosy declines in Morocco after implementation of preventive drug

Leprosy declines in Morocco after implementation of preventive drug

That change can be attributed to the implementation, beginning in 2012, of single dose rifampicin as a preventive to spread leprosy through households, researchers report in PLOS Neglected Tropical Diseases this week.

Control HIV by treating schistosomiasis, new study suggests

Control HIV by treating schistosomiasis, new study suggests

Now, researchers reporting in PLOS Neglected Tropical Diseases have shown that schistosomiasis infections are associated with increased HIV onward transmission, HIV acquisition in HIV negative women with urogenital schistosomiasis, and progression to death in HIV positive women.

Natural compound 2HF treats leishmaniasis infections, study finds

Natural compound 2HF treats leishmaniasis infections, study finds

Now, researchers reporting in PLOS Neglected Tropical Diseases have showed that a natural flavonoid is effective at treating Leishmania amazonensis infections. amazonensis parasite cells, and then went on to test the effectiveness of the compound in treating mice with L.

Human activity may influence the distribution and transmission of Bartonella bacteria

Human activity may influence the distribution and transmission of Bartonella bacteria

A study in PLOS Neglected Tropical Diseases by Hannah Frank and colleagues at Stanford University, California suggests that humans play an important role in disease risk, infection patterns, and distribution of Bartonella, advancing current understanding of Bartonella's evolutionary history and how the bacteria may be transmitted between humans and other animal species.

Prevalence of HTLV-1 infection among teens and adults in Gabon remains high

Prevalence of HTLV-1 infection among teens and adults in Gabon remains high

A study published in PLOS Neglected Tropical Diseases, by Mirdad Kazanji, of the Centre International de Recherches Medicales de Franceville in Gabon, and the Institut Pasteur de la Guyane in French Guiana, suggests that 30 years after the first epidemiological survey of the seroprevalence of Human T-cell lymphotropic virus type 1 (HTLV-1) infections in Gabon, the country remains highly endemic, with a seroprevalence of 7.3%.

Bug guts shed light on Central America Chagas disease

Bug guts shed light on Central America Chagas disease

By collecting DNA from the guts of these bugs, researchers reporting in PLOS Neglected Tropical Diseases have described patterns in the behavior of the bugs, the strain of parasite, and the communities of microbes that interact with the parasite.

Preventing a dengue outbreak at the 2020 Summer Olympics

Preventing a dengue outbreak at the 2020 Summer Olympics

Researchers report this week in PLOS Neglected Tropical Diseases that new controls and frameworks are recommended to detect dengue and other infectious diseases and help prevent their spread during the summer games. "We specifically applied the FMEA framework to health preparedness for dengue infection for Tokyo 2020.